26-Title: Intricacy in cross-bred cattle with presumptive lumpy skin disease and prospective antiviral role of ivermectin

Authors: Rashmi Rekha Kumari, Manoj Kumar Tripathi, Ravi Kumar, Prabhas Kumar, Manish Kumar, Abhay Kumar, Kamal Sarma and Pankaj Kumar

Source: Ruminant Science (2021)-10(2):375-382.

How to cite this manuscript: Kumari Rashmi Rekha, Tripathi Manoj Kumar, Kumar Ravi, Kumar Prabhas, Kumar Manish, Kumar Abhay, Sarma Kamal and Kumar Pankaj (2021). Intricacy in cross-bred cattle with presumptive lumpy skin disease and prospective antiviral role of ivermectin. Ruminant Science 10(2):375-382.

Abstract

Present study was undertaken on 40 cross-bred milch cattle exhibiting presumptive clinical signs of Lumpy skin disease (LSD)  to comprehend the associated intricacies and the feasible antiviral potential of ivermectin based on clinical response. The disease history, clinical signs, and production of animals were recorded. Clinical samples were collected for haemato-biochemical analysis, haemoparasitic examination and skin scraping. Cattle with presumptive LSD were grouped on the parameters of the severity of the animal’s clinical signs and health status in the range of 1+ to 4+. Further, to evaluate the antiviral effect of ivermectin and the modules for treatments, these were grouped into three uneven groups based on Giemsa stained blood smear (GSBS) microscopy results (I, II, III). Data generated were analysed statistically. The presumptive clinical signs of LSD included in the study were high fever, drop in milk yield, inappetence to anorexia, presence of skin lumps, enlargement of peripheral lymph node, etc. Among cattle with presumptive LSD, 15% were infected with mild to moderate Theileria spp., and 10% with Anaplasma marginale. The mortality rate was nil in presumptive LSD affected cattle. The haemoglobin and RBC count values in the cattle with presumptive LSD were lower and non-significantly different among groups. Leukopenia was non-significantly higher in cattle exhibiting greater severity of LSD like signs. The serum biochemical profile inferred muscle and liver damage in these cattle and the viremia influenced serum globulin, albumin and total protein levels. However, non-significant differences were observed between groups. Therapeutic response of ivermectin drug in different groups of cattle with presumptive LSD convey possible antiviral effect with early clinical and production recovery compared to the same module of supportive therapy without ivermectin.

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